NYT has an exclusive interview with Stephen Hawking. He composed his answers using a computer and movements of his cheek muscle.
Q. Given all you’ve experienced, what words would you offer someone who has been diagnosed with a serious illness, perhaps A.L.S.?
A. My advice to other disabled people would be, concentrate on things your disability doesn’t prevent you doing well, and don’t regret the things it interferes with. Don’t be disabled in spirit, as well as physically.
And here’s the same style interview from 2004.
Seriously, how do you keep your spirits up?
My expectations were reduced to zero when I was 21. Everything since then has been a bonus.